This study was done to evaluate the antibacterial activity of methanolic extract from the tissue of Litopenaeus vannamei against human pathogenic bacteria. The methanolic extract was examined for the antibacterial activity against 10 human bacterial strains such as Staphylococcus aureus, Klebsiella pneumoniae, Salmonella typhi, Vibrio cholerae, Klebsiella oxytoca, Escherichia coli, Salmonella paratyphi, Proteus mirabilis, Vibrio parahaemolyticus and Streptococcus pyogenes. The methanolic extract showed maximum antibacterial activity of 19 mm of inhibition zone against E. coli at 100 µg/ml concentration; whereas the lowest inhibition zone of 13 mm was recorded against S. paratyphi at the same concentration. The minimum inhibitory concentration (MIC) of the mehanolic extract recorded 60, 80, 100, 100, 100 and 100 µg/ml against bacterial strains such as E. coli, S. aureus, S. typhi, S. paratyphi, S. pyogenes and K. oxytoca respectively. In conclusion the methanolic extract from the tissue of L. vannamei have good antibiotic substances and it could be suggested as a source of active antibacterial as well as future drug in multidrug resistance human pathogens.
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